Using molecular transmission networks to understand the epidemic characteristics of HIV-1 CRF08_BC across China.

HIV-1 CRF08&#95;BC has become a major epidemic in heterosexuals and intravenous drug users (IDUs) in southern China. In order to evaluate the trends of its epidemic and facilitate targeted HIV prevention, we constructed the genetic transmission networks based on its pol sequences, derived from the National HIV Molecular Epidemiology Survey. Through retrospective network analysis, to study the epidemiological and demographic correlations with the transmission network. Of the 1,829 study subjects, 639 (34.9%) were clustered in 151 transmission networks. Factors associated with increased clustering include IDUs, heterosexual men, young adults and people with lower education ( P < 0.05 for all). The IDUs, MSM, young adult and person with low education had more potential transmission links as well ( P < 0.05 for all). The most crossover links were found between heterosexual women and IDUs, with 30.9% heterosexual women linked to IDUs. The crossover links heterosexual women were mainly those with middle age and single ( P < 0.001). This study indicated that the HIV-1 CRF08&#95;BC epidemic was still on going in China with more than one third of the infected people clustered in the transmission networks. Meanwhile, the study could help identify the active CRF08&#95;BC spreader in the local community and greatly facilitate précising AIDS prevention with targeted intervention.