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SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.
- Source :
-
Nature medicine [Nat Med] 2021 Apr; Vol. 27 (4), pp. 622-625. Date of Electronic Publication: 2021 Mar 02. - Publication Year :
- 2021
-
Abstract
- SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.
Details
- Language :
- English
- ISSN :
- 1546-170X
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33654292
- Full Text :
- https://doi.org/10.1038/s41591-021-01285-x