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Enhanced thrombin/PAR1 activity promotes G-CSF- and AMD3100-induced mobilization of hematopoietic stem and progenitor cells via NO upregulation.
- Source :
-
Leukemia [Leukemia] 2021 Nov; Vol. 35 (11), pp. 3334-3338. Date of Electronic Publication: 2021 Mar 02. - Publication Year :
- 2021
- Subjects :
- Animals
Anti-HIV Agents pharmacology
Apoptosis
Cell Proliferation
Cells, Cultured
Hematopoietic Stem Cells cytology
Hematopoietic Stem Cells drug effects
Mice
Receptor, PAR-1 genetics
Thrombin genetics
Benzylamines pharmacology
Cyclams pharmacology
Granulocyte Colony-Stimulating Factor pharmacology
Hematopoietic Stem Cell Mobilization methods
Hematopoietic Stem Cells physiology
Nitric Oxide metabolism
Receptor, PAR-1 metabolism
Thrombin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5551
- Volume :
- 35
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Leukemia
- Publication Type :
- Academic Journal
- Accession number :
- 33654208
- Full Text :
- https://doi.org/10.1038/s41375-021-01194-5