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Pneumatosis intestinalis in a radioactive iodine-refractory metastasic thyroid papillary carcinoma with BRAF V600E mutation treated with dabrafenib-trametinib: a case report.
- Source :
-
Journal of medical case reports [J Med Case Rep] 2021 Mar 02; Vol. 15 (1), pp. 109. Date of Electronic Publication: 2021 Mar 02. - Publication Year :
- 2021
-
Abstract
- Background: Pneumatosis intestinalis (PI) is a rare entity which refers to the presence of gas within the wall of the small bowel or colon which is a radiographic sign. The etiology and clinical presentation are variable. Patients with PI may present either with chronic mild non-specific symptoms or with acute abdominal pain with peritonitis. Some cases of intestinal pneumatosis have been reported as adverse events of new oncological treatments such as targeted therapies that are widely used in multiple tumors.<br />Case Presentation: A 59-year-old caucasian female with radioactive iodine-refractory metastatic thyroid papillary carcinoma with BRAF <superscript>V600E</superscript> mutation was treated with dabrafenib and trametinib as a compassionate use. After 4 months treatment, positron emission tomography-computed tomography (PET-CT) showed PI. At the time of diagnosis, the patient was asymptomatic without signs of peritonitis. The initial treatment was conservative and no specific treatment for PI was needed. Unfortunately, after dabrafenib-trametinib withdrawal, the patient developed tumor progression with significant clinical worsening.<br />Conclusions: This case report is, in our knowledge, the first description of PI in a patient treated with dabrafenib-trametinib. Conservative treatment is feasible if there are no abdominal symptoms.
- Subjects :
- Emphysema chemically induced
Female
Humans
Intestinal Diseases chemically induced
Iodine Radioisotopes therapeutic use
Middle Aged
Positron Emission Tomography Computed Tomography
Proto-Oncogene Proteins B-raf genetics
Skull Base Neoplasms diagnostic imaging
Skull Base Neoplasms genetics
Skull Base Neoplasms secondary
Thyroid Cancer, Papillary diagnostic imaging
Thyroid Cancer, Papillary genetics
Thyroid Cancer, Papillary secondary
Emphysema diagnostic imaging
Imidazoles adverse effects
Intestinal Diseases diagnostic imaging
Oximes adverse effects
Protein Kinase Inhibitors adverse effects
Pyridones adverse effects
Pyrimidinones adverse effects
Skull Base Neoplasms drug therapy
Thyroid Cancer, Papillary drug therapy
Thyroid Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1752-1947
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of medical case reports
- Publication Type :
- Academic Journal
- Accession number :
- 33653337
- Full Text :
- https://doi.org/10.1186/s13256-020-02581-9