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Health state utility and quality of life measures in patients with chronic myeloid leukemia in France.
- Source :
-
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2021 Jul; Vol. 30 (7), pp. 2021-2032. Date of Electronic Publication: 2021 Mar 02. - Publication Year :
- 2021
-
Abstract
- Purpose: Tyrosine kinase inhibitors (TKIs) have dramatically improved the prognosis of chronic myeloid leukemia (CML). We aimed to assess health state utility and quality of life (QoL) in French patients with CML in real-life setting, to study the determinants of utility score and to compare health-related QoL values to general population norms.<br />Methods: We conducted a cross-sectional study in 412 patients with CML. Data were collected by electronic survey. Three patient-reported outcomes questionnaires were used: EORTC QLQ-C30, EORTC QLQ-CML24 and EuroQol EQ-5D-3L. Health state utility values were computed using the French value set. We computed deviations from reference norms from the general population. We studied the determinants of health utility score using multiple regression models.<br />Results: The mean utility score (SD) was 0.72 (0.25) in the chronic phase and 0.84 (0.21) in treatment-free remission, with marked variations by gender. Patients with CML had a deviation from the reference norm of -0.15 on average (SD: 0.25). In terms of QoL, social functioning, role functioning and cognitive functioning were notably impacted with a mean difference of -16.0, -13.1 and -11.7 respectively. Fatigue, dyspnea and pain were the symptoms with the highest deviation from general population norms (mean difference of 20.6, 14.0 and 8.3 respectively). In the multiple regression analysis, fatigue was the most important independent predictor of the utility score.<br />Conclusion: Although TKIs prevent the disease from progressing and even allow remission without treatment, QoL in patients with CML is notably altered. The utility scores deteriorate with CML symptoms.
- Subjects :
- Cross-Sectional Studies
Female
France
Humans
Male
Middle Aged
Prospective Studies
Pyrazoles pharmacology
Pyrimidines pharmacology
Surveys and Questionnaires
Leukemia, Myelogenous, Chronic, BCR-ABL Positive psychology
Pyrazoles therapeutic use
Pyrimidines therapeutic use
Quality of Life psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2649
- Volume :
- 30
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 33651280
- Full Text :
- https://doi.org/10.1007/s11136-021-02794-5