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Multifocal in situ mantle cell neoplasia of the ileocecal region: a case report with simultaneous nodal and extranodal involvement.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Nov; Vol. 479 (5), pp. 1037-1040. Date of Electronic Publication: 2021 Mar 01. - Publication Year :
- 2021
-
Abstract
- In situ mantle cell neoplasia (ISMCN) is a rare entity of disputed clinical significance. We report an additional case, unusual by its presentation in the large intestine and its multifocal involvement of several nodal and extranodal sites. The diagnosis was made in a 46-year-old male patient from a surgical specimen resected for cecal adenocarcinoma. Gross examination showed multiple small polypoid lesions surrounding the ileocecal valve, corresponding to lymphoid aggregates with hyperplastic follicles. Numerous cyclin D1/SOX11+ lymphoid cells, harboring the t(11;14)(q13;q32) translocation, were present in the inner layers of mantle zones. The same lesions were found in the ileum, the appendix, and the regional lymph nodes. The final diagnosis was multifocal ISMCN of the ileocecal region, with both nodal and extra-nodal involvement. A simple surveillance was decided. Our observation expands the clinical spectrum of the disease and underlines the necessity to closely examine even normal-appearing reactive lymphoid tissues.<br /> (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.)
- Subjects :
- Adenocarcinoma chemistry
Adenocarcinoma genetics
Biomarkers, Tumor analysis
Biomarkers, Tumor genetics
Biopsy
Cecal Neoplasms chemistry
Cecal Neoplasms genetics
Diagnosis, Differential
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymphoid Tissue chemistry
Lymphoma, Mantle-Cell chemistry
Lymphoma, Mantle-Cell genetics
Male
Middle Aged
Predictive Value of Tests
Translocation, Genetic
Adenocarcinoma pathology
Cecal Neoplasms pathology
Lymphoid Tissue pathology
Lymphoma, Mantle-Cell pathology
Neoplasms, Multiple Primary
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2307
- Volume :
- 479
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Report
- Accession number :
- 33650040
- Full Text :
- https://doi.org/10.1007/s00428-021-03065-x