Development of electrospun core-shell polymeric mat using poly (ethyl-2) cyanoacrylate/polyurethane to attenuate biological adhesion on polymeric mesh implants.

Poly (ethyl-2) cyanoacrylate was used to create an adhesion-free biocompatible non-woven material reinforced by polyurethane core via a co-axial electrospinning set-up. The effect of relative humidity (RH) of (18, 30, 40, 60, and 68) % on the electrospinning process was examined, and found that in order to achieve well defined core-shell fiber structure, the optimal RH was 18%. If the RH is >18%, a phenomenon called Taylor cone cyclic destabilization occurs, which results in unfavorable surface and mechanical properties of the mat. The developed composite electrospun mat has the potential to be used in medical devices, such as repairing the viscera layer for intraperitoneal hernia mesh implants, which require the attenuation of biological elements, and adequate mechanical properties.
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