Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever.

Authors :: Lorenz N
Ho TKC
McGregor R
Davies MR
Williamson DA
Gurney JK
Smeesters PR
Baker MG
Moreland NJ
Source :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Dec 16; Vol. 73 (12), pp. 2322-2325.
Publication Year :: 2021
Abstract: Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.<br /> (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)

Subjects :: Antigens, Bacterial
Humans
Streptococcus pyogenes
Rheumatic Fever complications
Streptococcal Infections complications

Language :: English
ISSN :: 1537-6591
Volume :: 73
Issue :: 12
Database :: MEDLINE
Journal :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :: Academic Journal
Accession number :: 33639619
Full Text :: https://doi.org/10.1093/cid/ciab180

Full Text Access

Tools