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Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: Hypotheses and perspectives.
- Source :
-
Life sciences [Life Sci] 2021 May 01; Vol. 272, pp. 119251. Date of Electronic Publication: 2021 Feb 23. - Publication Year :
- 2021
-
Abstract
- A novel infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in December 2019 and declared as a global pandemic by the World Health. Approximately 15% of patients with COVID-19 progress to severe pneumonia and eventually develop acute respiratory distress syndrome (ARDS), septic shock and/or multiple organ failure with high morbidity and mortality. Evidence points towards a determinant pathogenic role of members of the renin-angiotensin system (RAS) in mediating the susceptibility, infection, inflammatory response and parenchymal injury in lungs and other organs of COVID-19 patients. The receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily, has important roles in pulmonary pathological states, including fibrosis, pneumonia and ARDS. RAGE overexpression/hyperactivation is essential to the deleterious effects of RAS in several pathological processes, including hypertension, chronic kidney and cardiovascular diseases, and diabetes, all of which are major comorbidities of SARS-CoV-2 infection. We propose RAGE as an additional molecular target in COVID-19 patients for ameliorating the multi-organ pathology induced by the virus and improving survival, also in the perspective of future infections by other coronaviruses.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
COVID-19 metabolism
COVID-19 pathology
Humans
Molecular Targeted Therapy
Multiple Organ Failure metabolism
Multiple Organ Failure pathology
Receptor for Advanced Glycation End Products metabolism
Renin-Angiotensin System drug effects
SARS-CoV-2 drug effects
Signal Transduction drug effects
COVID-19 Drug Treatment
COVID-19 complications
Drug Discovery
Multiple Organ Failure etiology
Multiple Organ Failure prevention & control
Receptor for Advanced Glycation End Products antagonists & inhibitors
SARS-CoV-2 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0631
- Volume :
- 272
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33636175
- Full Text :
- https://doi.org/10.1016/j.lfs.2021.119251