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Electrochemical Insight into Mechanisms and Metallocyclic Intermediates of C-H Functionalization.
- Source :
-
Chemical record (New York, N.Y.) [Chem Rec] 2021 Sep; Vol. 21 (9), pp. 2148-2163. Date of Electronic Publication: 2021 Feb 25. - Publication Year :
- 2021
-
Abstract
- Transition metal-catalyzed C-H activation has emerged as a powerful tool in organic synthesis and electrosynthesis as well as in the development of new methodologies for producing fine chemicals. In order to achieve efficient and selective C-H functionalization, different strategies have been used to accelerate the C-H activation step, including the incorporation of directing groups in the substrate that facilitate coordination to the catalyst. In this review, we try to underscore that the understanding the mechanisms of the catalytic cycle and the reactivity or redox activity of the key metal cyclic intermediates in these reactions is the basis for controlling the selectivity of synthesis and electrosynthesis. Combination of the electrosynthesis and voltammetry with traditional synthetic and physico-chemical methods allows one to achieve selective transformation of C-H bonds to functionalized C-C or C-X (X=heteroatom or halogen) bonds which may encourage organic chemists to use it in the future more often. The possibilities and the benefits of electrochemical techniques are analyzed and summarized.<br /> (© 2021 The Chemical Society of Japan & Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1528-0691
- Volume :
- 21
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Chemical record (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 33629800
- Full Text :
- https://doi.org/10.1002/tcr.202100009