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Alcohol withdrawal does not impede hippocampal granule cell progressive loss in chronic alcohol-fed rats.
- Source :
-
Neuroscience letters [Neurosci Lett] 1988 Mar 21; Vol. 86 (1), pp. 45-50. - Publication Year :
- 1988
-
Abstract
- Using the unbiased disector method we have shown that chronic alcohol consumption induces a significant decrease of dentate gyrus granule cell density in alcohol-fed rats for 18 months. A still more dramatic reduction was observed in a group of age-matched rats alcohol-fed for 12 months and switched to water for 6 months (recovery group). These results indicate that a progressive neuronal loss of the hippocampal granule cells in not impeded after cessation of alcohol intake. It is thus suggested that once the mechanisms underlying the alcohol-induced neuronal degeneration are triggered, they continue to act even after withdrawal.
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 86
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 3362427
- Full Text :
- https://doi.org/10.1016/0304-3940(88)90180-2