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Alcohol withdrawal does not impede hippocampal granule cell progressive loss in chronic alcohol-fed rats.

Authors :
Cadete-Leite A
Tavares MA
Paula-Barbosa MM
Source :
Neuroscience letters [Neurosci Lett] 1988 Mar 21; Vol. 86 (1), pp. 45-50.
Publication Year :
1988

Abstract

Using the unbiased disector method we have shown that chronic alcohol consumption induces a significant decrease of dentate gyrus granule cell density in alcohol-fed rats for 18 months. A still more dramatic reduction was observed in a group of age-matched rats alcohol-fed for 12 months and switched to water for 6 months (recovery group). These results indicate that a progressive neuronal loss of the hippocampal granule cells in not impeded after cessation of alcohol intake. It is thus suggested that once the mechanisms underlying the alcohol-induced neuronal degeneration are triggered, they continue to act even after withdrawal.

Details

Language :
English
ISSN :
0304-3940
Volume :
86
Issue :
1
Database :
MEDLINE
Journal :
Neuroscience letters
Publication Type :
Academic Journal
Accession number :
3362427
Full Text :
https://doi.org/10.1016/0304-3940(88)90180-2