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68 Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2021 May; Vol. 158, pp. 55-61. Date of Electronic Publication: 2021 Feb 20. - Publication Year :
- 2021
-
Abstract
- Background and Purpose: To compare <superscript>68</superscript> Ga-fibroblast activation protein inhibitor (FAPI) and <superscript>18</superscript> F-FDG PET/CT in imaging locally advanced oesophageal cancer, and evaluate the potential usefulness of <superscript>68</superscript> Ga-FAPI PET/CT on gross target volume (GTV) delineation aimed at radiotherapy planning for oesophageal cancer as compared with contrast-enhanced CT (CE-CT) and <superscript>18</superscript> F-FDG PET/CT.<br />Materials and Methods: Twenty-one patients with newly diagnosed oesophageal cancer who underwent both <superscript>18</superscript> F-FDG and <superscript>68</superscript> Ga-FAPI PET/CT scans were selected. GTVs of the primary tumours based on CE-CT (GTV <subscript>CT</subscript> ), PET/CT, and CE-CT plus PET/CT were delineated. Gross tumour lengths were measured by GTVs and endoscopy and recorded.<br />Results: The <superscript>68</superscript> Ga-FAPI PET showed significantly higher radiotracer uptake than <superscript>18</superscript> F-FDG PET (median SUVmax 16.71 vs. 11.23; P = 0.002) in the primary tumours. SUV thresholds of FAPI ×20%, 30%, 40%, and FDG ×40% showed similar lesion lengths compared with that in endoscopic examination (P > 0.05). GTV <subscript>CT</subscript> demonstrated the largest volume (median: 48.80 mm <superscript>3</superscript> , range: 14.83-162.23 mm <superscript>3</superscript> ) than PET-based GTVs. For PET/CT-guided complementary contouring of GTV <subscript>CT</subscript> , four patients (19%) were increased by FAPI ×20% and 30%, two patients (9.5%) were increased by FAPI ×40%, and only one patient was increased by FDG ×40%. Furthermore, the volume of GTV based on CE-CT plus FAPI ×20%, 30%, and 40% showed no significant difference with GTV <subscript>CT</subscript> and planning target volume based CE-CT plus FAPI-PET and meets the organ at risk standard.<br />Conclusion: The <superscript>68</superscript> Ga-FAPI PET/CT methodology showed favourable tumour-to-background contrast in oesophageal cancer and might provide additional information for target volume delineation and help avoid tumour geographic misses.<br /> (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 158
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 33621587
- Full Text :
- https://doi.org/10.1016/j.radonc.2021.02.015