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ABC transporter superfamily. An updated overview, relevance in cancer multidrug resistance and perspectives with personalized medicine.
- Source :
-
Molecular biology reports [Mol Biol Rep] 2021 Feb; Vol. 48 (2), pp. 1883-1901. Date of Electronic Publication: 2021 Feb 22. - Publication Year :
- 2021
-
Abstract
- The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters family found in humans. These proteins actively transport endogenous and exogenous substrates through biological membranes in body tissues, so they have an important role in the regulation of many physiological functions necessary for human homeostasis, as well as in response regulation to several pharmacological substrates. The development of multidrug resistance has become one of the main troubles in conventional chemotherapy in different illnesses including cancer, being the increased efflux of antineoplastic drugs the main reason for this multidrug resistance, with a key role of the ABC superfamily. Likely, the interindividual variability in the pharmacological response among patients is well known, and may be due to intrinsically factors of the disease, genetic and environmental ones. Thus, the understanding of this variability, especially the genetic variability associated with the efficacy and toxicity of drugs, can provide a safer and more effective pharmacological treatment, so ABC genes are considered as important regulators due to their relationship with the reduction in pharmacological response. In this review, updated information about transporters belonging to this superfamily was collected, the possible role of these transporters in cancer, the role of genetic variability in their genes, as well as some therapeutic tools that have been tried to raise against main transporters associated with chemoresistance in cancer.
- Subjects :
- ATP-Binding Cassette Transporters antagonists & inhibitors
Antineoplastic Agents adverse effects
Drug Resistance, Multiple genetics
Humans
Neoplasms genetics
Pharmacogenetics methods
ATP-Binding Cassette Transporters genetics
ATP-Binding Cassette Transporters metabolism
Antineoplastic Agents pharmacology
Drug Resistance, Neoplasm genetics
Neoplasms drug therapy
Neoplasms metabolism
Precision Medicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4978
- Volume :
- 48
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Molecular biology reports
- Publication Type :
- Academic Journal
- Accession number :
- 33616835
- Full Text :
- https://doi.org/10.1007/s11033-021-06155-w