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Elimination and metabolism of a fat emulsion containing medium chain triglycerides (lipofundin MCT 10%).
- Source :
-
JPEN. Journal of parenteral and enteral nutrition [JPEN J Parenter Enteral Nutr] 1988 Mar-Apr; Vol. 12 (2), pp. 116-20. - Publication Year :
- 1988
-
Abstract
- Medium chain triglycerides (MCT) are supposed to be advantageous on account of rapid energy supply in parental nutrition. However, data on the elimination rate of MCT-containing emulsions during an intravenous fat-tolerance test (IVFTT) are scarce. We performed this test (0.1 g lipid/kg body weight) in 18 young healthy volunteers (nine females and nine males) using Lipofundin MCT 10% (50% MCT; egg phospholipids as emulsifier). Our results indicate that both elimination and metabolization of the emulsion are fast: a prompt decrease of light-scattering index and of triglyceride concentrations in serum, an immediate appearance of post-load fatty acids and of beta-hydroxybutyrate were observed. This was in good agreement with the findings obtained during 6-hr infusions in the same probands. Fractional elimination rates k2 obtained from light-scattering indices are 7.29 +/- 2.73%/min in males and 11.59 +/- 3.38%/min in females, indicating a higher removal capacity in women. In the same subjects, the corresponding k2 values for Lipofundin S 10% (containing only long chain triglycerides) were higher, reflecting an elimination rate that is faster due to the use of soya bean phospholipids as emulsifier. In comparison, k2 values based on the course of the triglyceride concentrations are generally lower.
- Subjects :
- 3-Hydroxybutyric Acid
Adult
Drug Combinations metabolism
Fatty Acids, Nonesterified blood
Female
Glycerol blood
Humans
Hydroxybutyrates metabolism
Light
Male
Metabolic Clearance Rate
Scattering, Radiation
Sex Characteristics
Triglycerides administration & dosage
Fat Emulsions, Intravenous metabolism
Phospholipids metabolism
Sorbitol metabolism
Triglycerides metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0148-6071
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- JPEN. Journal of parenteral and enteral nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 3361679
- Full Text :
- https://doi.org/10.1177/0148607188012002116