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ELABELA alleviates syncytiotrophoblast hypoxia/reoxygenation injury and preeclampsia-like symptoms in mice by reducing apoptosis.
- Source :
-
Placenta [Placenta] 2021 Mar; Vol. 106, pp. 30-39. Date of Electronic Publication: 2021 Feb 11. - Publication Year :
- 2021
-
Abstract
- Introduction: Preeclampsia (PE) is associated with increased syncytiotrophoblast apoptosis. ELABELA (ELA) is a circulating hormone secreted by the placenta. Here, we investigated the involvement of ELA in the pathogenesis of PE.<br />Methods: We measured ELA expression in the placental villi of patients with severe PE and healthy controls. A cellular model of hypoxia and reoxygenation was used to simulate PE hypoxia, and changes in the proliferation and apoptosis of trophoblasts in response to different ELA concentrations were measured. In addition, we used NG-nitro-l-arginine methyl ester (l-NAME) to generate a mouse model of pregnancy-induced hypertension and explore whether ELA can improve the symptoms of PE.<br />Results: ELA expression was decreased in severe PE. ELA promoted the proliferation of BeWo cells and improved the decreased cell proliferation rate after hypoxia/reoxygenation injury. ELA reversed the phenotypes of l-NAME-induced PE mice and regulated the expression of mouse placental apoptosis factors.<br />Discussion: ELA reduced apoptosis in BeWo cells and improved PE-like symptoms in mice, suggesting its value as a potential novel treatment for PE.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Apoptosis physiology
Cell Line
Disease Models, Animal
Female
Humans
Hypoxia metabolism
Mice
NG-Nitroarginine Methyl Ester pharmacology
Peptide Hormones metabolism
Peptide Hormones therapeutic use
Placenta metabolism
Pre-Eclampsia metabolism
Pregnancy
Trophoblasts metabolism
Apoptosis drug effects
Hypoxia drug therapy
Peptide Hormones pharmacology
Placenta drug effects
Pre-Eclampsia drug therapy
Trophoblasts drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3102
- Volume :
- 106
- Database :
- MEDLINE
- Journal :
- Placenta
- Publication Type :
- Academic Journal
- Accession number :
- 33610935
- Full Text :
- https://doi.org/10.1016/j.placenta.2021.02.002