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Effect of the Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (NIFTP) Nomenclature Revision on Indian Thyroid Fine-Needle Aspiration Practice.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2021 Jul 06; Vol. 156 (2), pp. 320-327. - Publication Year :
- 2021
-
Abstract
- Objectives: To analyze risk of malignancy (ROM) in Bethesda categories (BCs) and the impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) reclassification on malignancy risk and surgical outcome.<br />Methods: In this retrospective study based on fine-needle aspiration samples with histologic follow-up, ROM was analyzed in BCs. Possible cases of NIFTP were reviewed, followed by the analysis of impact of this reclassification on ROM in BCs.<br />Results: The incidence of NIFTP was 6.9% among excised thyroid nodules and 16.8% among all resected neoplastic lesions. ROM for BCs I to VI was 37.5%, 9.6%, 40.0%, 46.5%, 88.8%, and 96.8%, respectively. Risk of neoplasia was 50.0%, 13.8%, 55.0%, 71.2%, 88.8%, and 96.8% respectively. When NIFTPs were considered nonmalignant lesions, ROM decreased by 6.3%, 4.3%, 20%, 19.1%, 22.5%, and 1.5% in each Bethesda category (I-VI), respectively. Inability to diagnose NIFTP preoperatively led to overtreatment in 16.2%.<br />Conclusions: Prevalence of NIFTP in Asian countries may be higher than expected. Substantial cases of NIFTP have a benign preoperative cytology; hence, cases of follicular adenoma and adenomatous colloid nodule should be included in the review. NIFTP reclassification has significantly reduced the ROM in indeterminate BCs, suggesting diagnostic lobectomy rather than total thyroidectomy. Countries should establish their own malignancy risk range and parameters.<br /> (© American Society for Clinical Pathology, 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adenocarcinoma, Follicular epidemiology
Adolescent
Adult
Aged
Aged, 80 and over
Biopsy, Fine-Needle
Child
Child, Preschool
Female
Humans
Incidence
India epidemiology
Male
Middle Aged
Prevalence
Retrospective Studies
Terminology as Topic
Thyroid Neoplasms epidemiology
Young Adult
Adenocarcinoma, Follicular classification
Adenocarcinoma, Follicular pathology
Thyroid Neoplasms classification
Thyroid Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1943-7722
- Volume :
- 156
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 33608707
- Full Text :
- https://doi.org/10.1093/ajcp/aqaa241