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Infective endocarditis by Klebsiella species: a systematic review.
- Source :
-
Journal of chemotherapy (Florence, Italy) [J Chemother] 2021 Oct; Vol. 33 (6), pp. 365-374. Date of Electronic Publication: 2021 Feb 19. - Publication Year :
- 2021
-
Abstract
- This study aimed to systematically analyze all cases of infective endocarditis (IE) by Klebsiella species in the literature. A systematic review of PubMed, Scopus and Cochrane library (through 27 <superscript>th</superscript> January 2021) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of IE by Klebsiella species was performed. In this review, a total of 66 studies were included, providing data for 67 patients. A prosthetic valve was present in 16.4%, while the most common causative pathogen was K. pneumoniae followed by K. oxytoca . The aortic valve was the most commonly infected intracardiac site, followed by the mitral valve. The diagnosis was based on transthoracic echocardiography in 46.2%, while the diagnosis was set at autopsy in 9.2% of included patients. Blood cultures were positive in 93.8%. Fever and sepsis were the most frequent clinical presentations, followed by embolic phenomena, paravalvular abscess, and heart failure. Cephalosporins, aminoglycosides, and carbapenems were the most frequently used antimicrobials. Surgical treatment along with antimicrobials was performed in 37.3% of included patients. Clinical cure was noted in 80.3%, while the overall mortality was 19.4%. Infection at the aortic valve was independently associated with mortality by IE. This systematic review gives a comprehensive description of IE by Klebsiella and provides information on epidemiology, clinical manifestations, therapeutic strategies and their outcomes.
- Subjects :
- Anti-Bacterial Agents therapeutic use
Aortic Valve
Blood Culture
Echocardiography
Endocarditis, Bacterial mortality
Endocarditis, Bacterial therapy
Heart Valve Prosthesis microbiology
Humans
Klebsiella Infections mortality
Klebsiella Infections therapy
Risk Factors
Endocarditis, Bacterial microbiology
Endocarditis, Bacterial physiopathology
Klebsiella Infections microbiology
Klebsiella Infections physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1973-9478
- Volume :
- 33
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of chemotherapy (Florence, Italy)
- Publication Type :
- Academic Journal
- Accession number :
- 33602044
- Full Text :
- https://doi.org/10.1080/1120009X.2021.1888025