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Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia.

Authors :
Morales-Nebreda L
Helmin KA
Torres Acosta MA
Markov NS
Hu JY
Joudi AM
Piseaux-Aillon R
Abdala-Valencia H
Politanska Y
Singer BD
Source :
JCI insight [JCI Insight] 2021 Mar 22; Vol. 6 (6). Date of Electronic Publication: 2021 Mar 22.
Publication Year :
2021

Abstract

Regulatory T (Treg) cells orchestrate resolution and repair of acute lung inflammation and injury after viral pneumonia. Compared with younger patients, older individuals experience impaired recovery and worse clinical outcomes after severe viral infections, including influenza and SARS coronavirus 2 (SARS-CoV-2). Whether age is a key determinant of Treg cell prorepair function after lung injury remains unknown. Here, we showed that aging results in a cell-autonomous impairment of reparative Treg cell function after experimental influenza pneumonia. Transcriptional and DNA methylation profiling of sorted Treg cells provided insight into the mechanisms underlying their age-related dysfunction, with Treg cells from aged mice demonstrating both loss of reparative programs and gain of maladaptive programs. Strategies to restore youthful Treg cell functional programs could be leveraged as therapies to improve outcomes among older individuals with severe viral pneumonia.

Details

Language :
English
ISSN :
2379-3708
Volume :
6
Issue :
6
Database :
MEDLINE
Journal :
JCI insight
Publication Type :
Academic Journal
Accession number :
33600379
Full Text :
https://doi.org/10.1172/jci.insight.141690