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Incidence of urinary tract infection in neonates with significant indirect Hyperbilirubinemia of unknown etiology: case-control study.
- Source :
-
Italian journal of pediatrics [Ital J Pediatr] 2021 Feb 17; Vol. 47 (1), pp. 35. Date of Electronic Publication: 2021 Feb 17. - Publication Year :
- 2021
-
Abstract
- Background: Indirect hyperbilirubinemia is frequently encountered during neonatal period. Although it has different causes, in some cases it can't be explained. Previous studies have illustrated that jaundice could be a major sign of urinary tract infection (UTI) in neonates.<br />Aim of the Work: We aimed to determine the association between UTI and significant unexplained neonatal indirect hyperbilirubinemia.<br />Methods: This prospective controlled study was performed on 150 neonates divided in two groups (100 as cases and 50 as controls) to investigate the incidence of UTI in neonates with significant unexplained hyperbilirubinemia. Urine sample was obtained using urine catheterization technique from neonates and full urine analysis was done and cases with pyuria had urine culture to confirm UTI. Immediate renal ultrasonography (USG) was performed for neonates with UTI.<br />Results: UTI incidence was 11% in cases while none of neonates in control group had UTI with statistical significance between cases and controls (P value < 0.05). The most common (36.4%) pathogen was Escherichia coli. Posterior urethral valve with mild hydronephrosis was diagnosed in 18.2% of UTI positive patients by renal ultrasonography.<br />Conclusion: In neonates with unexplained indirect hyperbilirubinemia, UTI should be considered as a pathological cause.
- Subjects :
- Bacteria isolation & purification
Case-Control Studies
Egypt epidemiology
Female
Humans
Hyperbilirubinemia, Neonatal urine
Incidence
Infant, Newborn
Male
Prospective Studies
Urinalysis
Urinary Tract Infections etiology
Urinary Tract Infections microbiology
Urine microbiology
Hyperbilirubinemia, Neonatal complications
Urinary Tract Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1824-7288
- Volume :
- 47
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Italian journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 33596989
- Full Text :
- https://doi.org/10.1186/s13052-021-00982-0