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Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals.
- Source :
-
Nature communications [Nat Commun] 2021 Feb 16; Vol. 12 (1), pp. 1050. Date of Electronic Publication: 2021 Feb 16. - Publication Year :
- 2021
-
Abstract
- Attributing the similarity between individuals to genetic and non-genetic factors is central to genetic analyses. In this paper we use the genomic relationship ([Formula: see text]) among 417,060 individuals to investigate the phenotypic covariance between pairs of individuals for 32 traits across the spectrum of relatedness, from unrelated pairs through to identical twins. We find linear relationships between phenotypic covariance and [Formula: see text] that agree with the SNP-based heritability ([Formula: see text]) in unrelated pairs ([Formula: see text]), and with pedigree-estimated heritability in close relatives ([Formula: see text]). The covariance increases faster than [Formula: see text] in distant relatives ([Formula: see text]), and we attribute this to imperfect linkage disequilibrium between causal variants and the common variants used to construct [Formula: see text]. We also examine the effect of assortative mating on heritability estimates from different experimental designs. We find that full-sib identity-by-descent regression estimates for height (0.66 s.e. 0.07) are consistent with estimates from close relatives (0.82 s.e. 0.04) after accounting for the effect of assortative mating.
- Subjects :
- Adult
Aged
Biological Specimen Banks
Body Mass Index
Educational Status
Humans
Inheritance Patterns genetics
Linkage Disequilibrium
Middle Aged
Models, Genetic
Phenotype
Polymorphism, Single Nucleotide genetics
Quantitative Trait, Heritable
Regression Analysis
United Kingdom
Genome, Human
Phylogeny
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 33594080
- Full Text :
- https://doi.org/10.1038/s41467-021-21283-4