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Methylmercury-induced movement and postural disorders in developing rat: regional analysis of brain catecholamines and indoleamines.
- Source :
-
Brain research [Brain Res] 1988 Jan 26; Vol. 439 (1-2), pp. 138-46. - Publication Year :
- 1988
-
Abstract
- Subcutaneous administration of methylmercury (MeHg) to rats during early postnatal development resulted in movement and postural disorders by day 22-24. Tissue concentrations of norepinephrine (NE), serotonin (5-HT), dopamine (DA) and selected metabolites were measured in the cerebral cortex, spinal cord and caudate-putamen at the onset of neurological impairment and at two subclinical stages of toxicity. In the cerebral cortex there was a significant increase in tissue concentrations of 5-HT (54-81%) and 5-hydroxyindoleacetic acid (HIAA, 133-178%) at the onset of neurological impairment. Similar increases were detected in the spinal cord for 5-HT (19-43%) and HIAA (98-123%) as well as an increase in the concentration of NE (42-51%). In the caudate-putamen there were significant increases in the concentrations of NE (98-116%), HIAA (108-124%) and DA (28-29%) with a significant decrease in the concentration of 3,4-dihydroxyphenylacetic acid (DOPAC, 20-27%); however, tissue levels of homovanillic acid (HVA) did not change significantly. Many of these changes were detected at subclinical stages of MeHg toxicity. The ratio of HIAA/5-HT, which is frequently used as an estimate of turnover for 5-HT, was significantly increased in all 3 tissues at the onset of neurological impairment (38-94%) and at one subclinical stage (47-114%). The ratio of (DOPAC + HVA)/DA was significantly decreased in caudate-putamen at all 3 stages of toxicity (18-40%). These changes indicate altered metabolism in aromatic amine systems in the developing central nervous system during the pathogenesis of MeHg-induced movement and postural disorder.
- Subjects :
- Aging
Animals
Body Weight drug effects
Brain drug effects
Brain pathology
Organ Size drug effects
Posture
Rats
Rats, Inbred Strains
Reference Values
Spinal Cord drug effects
Spinal Cord pathology
Biogenic Amines metabolism
Brain growth & development
Catecholamines metabolism
Dyskinesia, Drug-Induced metabolism
Methylmercury Compounds toxicity
Spinal Cord growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 439
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 3359179
- Full Text :
- https://doi.org/10.1016/0006-8993(88)91470-9