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The structure of mononuclear phagocytes differentiating in vivo. III. The effect of particulate foreign substances.
- Source :
-
The American journal of pathology [Am J Pathol] 1977 Nov; Vol. 89 (2), pp. 335-50. - Publication Year :
- 1977
-
Abstract
- The response of mononuclear phagocytes to three inert particles--barium sulfate, talc, and thorium dioxide--was studied by correlated light and electron microscopy. All three particles induced maturation of the mononuclear phagocytes, which proceeded to the stage of the mature macrophage and required 7 to 9 days. Once established, maturation persisted as long as 45 days, as did the inert particles. The resultant lesions, dense aggregates of mature macrophages, were termed mature granulomas. The resultant maturation differed from that produced by digestible bacteria in tempo and extent but not in pattern.
- Subjects :
- Animals
Barium Sulfate
Cell Differentiation
Foreign-Body Reaction pathology
Granuloma pathology
Guinea Pigs
Macrophages immunology
Macrophages ultrastructure
Phagocytes immunology
Phagocytosis
Talc
Thorium Dioxide
Time Factors
Foreign-Body Reaction immunology
Granuloma immunology
Phagocytes ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9440
- Volume :
- 89
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 335889