Start Over

The ECG Characteristics of Patients With Isolated Hypomagnesemia.

Authors :: Yang Y
Chen C
Duan P
Thapaliya S
Gao L
Dong Y
Yin X
Yang X
Zhang R
Tan R
Hui S
Wang Y
Sutton R
Xia Y
Source :: Frontiers in physiology [Front Physiol] 2021 Jan 27; Vol. 11, pp. 617374. Date of Electronic Publication: 2021 Jan 27 (Print Publication: 2020).
Publication Year :: 2021
Abstract: Background: Electrocardiographic (ECG) characteristics of patients with isolated hypomagnesemia are not well defined. We aimed to investigate these ECG characteristics in order to define clearly the features of isolated hypomagnesemia. Hypothesis: Lower serum magnesium could affect ECG parameters after excluding potential confounders. Methods: This retrospective study was of patients with low serum magnesium <0.65 mmol/L compared with the same patients after restoration to normal serum magnesium. Patients with hypokalemia, hypocalcemia and other electrolyte disturbances were excluded. ECG parameters manually determined and analyzed were P wave dispersion, PR interval, QRS duration, ST-T changes, T wave amplitude, T peak-to-end interval (Tpe), corrected Tpe (Tpec), QT, corrected QT (QTc), QT peak corrected (QTpc) and Tpe dispersion, Tpe/QT ratio. Results: Two-hundred-and-fourteen patients with isolated hypomagnesemia were identified with 50 of them (56.9 ± 13.6 years; 25 males) being eligible for final analysis from 270,997 patients presenting April 2011-October 2017. In the period of isolated hypomagnesemia, P wave duration was found prolonged ( p ≤ 0.02); as was QTc (439 ± 27 vs. 433 ± 22, p = 0.01). Tpec (122 ± 24vs. 111 ± 22, p = 0.000) and Tpe/QT ratio (0.29 ± 0.05 vs. 0.27 ± 0.05, p = 0.000) were increased. QTpc decreased during hypomagnesemia (334 ± 28 vs. 342 ± 21, p = 0.02). However, no significant differences were found in PR interval, QRS duration (85 ± 12 ms vs. 86 ± 12 ms, p = 0.122) and ST-T segments between the patients and their own controls. Conclusions: In patients with isolated hypomagnesemia, P wave duration, QTc, Tpec, and Tpe/QT ratio suggesting atrial depolarization and ventricular repolarization dispersion were significantly increased compared with normal magnesium levels in the same patients after restoration to normal levels. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Yang, Chen, Duan, Thapaliya, Gao, Dong, Yin, Yang, Zhang, Tan, Hui, Wang, Sutton and Xia.)