Anti-inflammatory constituents from Phyllostachys makinoi Hayata.

A novel chromone analogue, phyllomakin A ( 1 ), and a new flavonolignan, (-)-quiquelignan C ( 2 ), along with 18 phenolic and 2 triterpenoids, were isolated from the leaves of Phyllostachys makinoi Hayata. The structures of 1 - 22 were elucidated by an application of various spectroscopic analyses (1D & 2D NMR and MS) and compared with reported data. A biological evaluation showed that compound 3 had very potent anti-NO production activity (IC ₅₀ = 4.80 µM), while compounds 2 , 6 , 11 , and 15 showed moderate inhibitory effects (IC ₅₀ = 10.19, 13.26, 13.56, and 10.96 µM, respectively) without affecting cell viability at 20 μM.