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Impact of Right Ventricular Dysfunction on Outcomes After Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation.
- Source :
-
JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2021 Apr; Vol. 14 (4), pp. 768-778. Date of Electronic Publication: 2021 Feb 10. - Publication Year :
- 2021
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Abstract
- Objectives: This study sought to assess the impact of right ventricular dysfunction (RVD) as defined by impaired right ventricular-to-pulmonary artery (RV-PA) coupling, on survival after edge-to-edge transcatheter mitral valve repair (TMVR) for severe secondary mitral regurgitation (SMR).<br />Background: Conflicting data exist regarding the benefit of TMVR in severe SMR. A possible explanation could be differences in RVD.<br />Methods: Using data from the EuroSMR (European Registry on Outcomes in Secondary Mitral Regurgitation) registry, this study compared the characteristics and outcomes of SMR patients undergoing TMVR, according to their RV-PA coupling, assessed by tricuspid annular plane systolic excursion-to-systolic pulmonary artery pressure (TAPSE/sPAP) ratio.<br />Results: Overall, 817 patients with severe SMR and available RV-PA coupling assessment underwent TMVR in the participating centers. RVD was present in 211 patients (25.8% with a TAPSE/sPAP ratio <0.274 mm/mm Hg). Although all patients demonstrated significant improvement in their New York Heart Association (NYHA) functional class, there was a trend toward a lower rate of NYHA functional class I or II among patients with RVD (56.5% vs. 65.5%, respectively; p = 0.086) after TMVR. Survival rates at 1 and 2 years were lower among patients with RVD (70.2% vs. 84.0%, respectively; p < 0.001; and 53.4% vs. 73.1%, respectively; p < 0.001). On multivariate analysis, a reduced TAPSE/sPAP ratio was a strong predictor of mortality (odds ratio: 1.62; 95% confidence interval: 1.14 to 2.31; p = 0.007).<br />Conclusions: RVD, as shown by impairment of RV-PA coupling, is a major predictor of adverse outcome in patients undergoing TMVR for severe SMR. The often neglected functional and anatomic RV parameters should be systematically assessed when planning TMVR procedures for patients with severe SMR.<br />Competing Interests: Funding Support and Author Disclosures Dr. Karam is a consultant for Abbott Vascular. Dr. Orban has received speaker fees from Abbott Vascular. Dr. Windecker has received research and educational grants from Abbott, Amgen, Bristol Myers Squibb, Bayer, Boston Scientific, Biotronik, CSL, Medtronic, Edwards Lifesciences, Sinomed, and Polares. Dr. Pfister has received financial support for attending symposia by Abbot Vascular. Dr. von Bardeleben has received speaker fees from Abbott Vascular and Edwards Lifesciences. Dr. Hausleiter has received research support and speaker honoraria from Abbott Vascular and Edwards Lifesciences. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.<br /> (Copyright © 2021. Published by Elsevier Inc.)
- Subjects :
- Humans
Predictive Value of Tests
Treatment Outcome
Cardiac Surgical Procedures
Mitral Valve Insufficiency diagnostic imaging
Mitral Valve Insufficiency etiology
Mitral Valve Insufficiency surgery
Ventricular Dysfunction, Right diagnostic imaging
Ventricular Dysfunction, Right etiology
Ventricular Dysfunction, Right surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1876-7591
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- JACC. Cardiovascular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 33582067
- Full Text :
- https://doi.org/10.1016/j.jcmg.2020.12.015