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Qi-Long-Tian formula extract alleviates symptoms of acute high-altitude diseases via suppressing the inflammation responses in rat.
- Source :
-
Respiratory research [Respir Res] 2021 Feb 12; Vol. 22 (1), pp. 52. Date of Electronic Publication: 2021 Feb 12. - Publication Year :
- 2021
-
Abstract
- Background: Chinese Yunnan Province, located in the Yunnan-Guizhou Plateau, is a famous tourist paradise where acute high-altitude illness common occurs among lowland people visitors due to non-acclimatization to the acute hypobaric hypoxia (AHH) conditions. Traditional Chinese medicine, such as Qi-Long-Tian (QLT) formula, has shown effectiveness and safety in the treatment of acute high-altitude diseases. The aim of this study was to clarify the therapeutic mechanisms of this traditional formula using a rat model in a simulated plateau environment.<br />Methods: Following testing, lung tissue samples were evaluated by hematoxylin-eosin staining and for biochemical characteristics. mRNA-Seq was used to compare differentially expressed genes in control rats, and in rats exposed to AHH and AHH with QLT treatment.<br />Results: Inflammation-related effectors induced following QLT treatment for AHH included MMP9 and TIMP1, and involved several phosphorylation signaling pathways implicated in AHH pathogenesis such as PI3K/AKT and MAPK signaling.<br />Conclusion: This study provides insights into the major signaling pathways induced by AHH and in the protective mechanisms involved in QLT formula activity.
- Subjects :
- Altitude Sickness pathology
Animals
Drugs, Chinese Herbal isolation & purification
Drugs, Chinese Herbal pharmacology
Inflammation drug therapy
Inflammation metabolism
Inflammation pathology
Inflammation Mediators antagonists & inhibitors
Lung drug effects
Lung pathology
Male
Rats
Rats, Wistar
Altitude
Altitude Sickness drug therapy
Altitude Sickness metabolism
Drugs, Chinese Herbal therapeutic use
Inflammation Mediators metabolism
Lung metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1465-993X
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Respiratory research
- Publication Type :
- Academic Journal
- Accession number :
- 33579290
- Full Text :
- https://doi.org/10.1186/s12931-021-01645-8