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Metabolomics data complemented drug use information in epidemiological databases: pilot study of potential kidney donors.
- Source :
-
Journal of clinical epidemiology [J Clin Epidemiol] 2021 Jul; Vol. 135, pp. 10-16. Date of Electronic Publication: 2021 Feb 09. - Publication Year :
- 2021
-
Abstract
- Objective: The objective of this study was to investigate whether clinical metabolomics, which is increasingly applied in population-based and epidemiological studies, can be used to provide analytical evidence of exposures, and whether such information can be useful to strengthen and/or complement corresponding clinical database entries, taking drug use as an example.<br />Study Design and Setting: Liquid chromatography-mass spectrometry (LC-MS) metabolomics analyses were performed on urine from 100 randomly-selected control subjects (50% females) from the TransplantLines Food and Nutrition Biobank and Cohort Study (NCT identifier 'NCT02811835'), and drugs were identified through spectral library searching and targeted signal extraction.<br />Results: In 83 subjects for whom drug use information was available, 22 expected and 26 unexpected prescription-only drugs were identified, while 28 expected prescription-only drugs remained undetected. In addition, 7 prescription-only drugs were found in 17 subjects for whom drug use information was unavailable, and 58 over-the-counter drugs were identified in all 100 subjects.<br />Conclusion: Molecular evidence for many drugs could be retrieved from LC-MS metabolomics data, which could be useful to complement and strengthen epidemiological databases given that considerable discrepancies were found between analytically-identified drugs and drugs listed in the available clinical database.<br /> (Copyright © 2021. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1878-5921
- Volume :
- 135
- Database :
- MEDLINE
- Journal :
- Journal of clinical epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 33577985
- Full Text :
- https://doi.org/10.1016/j.jclinepi.2021.02.008