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Operationalization of a frailty index in patients with multiple sclerosis: A cross-sectional investigation.
- Source :
-
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2021 Oct; Vol. 27 (12), pp. 1939-1947. Date of Electronic Publication: 2021 Feb 10. - Publication Year :
- 2021
-
Abstract
- Background: Frailty is an age-related status of increased vulnerability to stressors caused by the accumulation of multiple health deficits. This construct may allow to capture the clinical complexity of patients with multiple sclerosis (MS).<br />Objective: To investigate the relationship between frailty and the clinical manifestations of MS.<br />Methods: Patients with MS were consecutively enrolled at five tertiary dedicated services. Disability and fatigue were assessed. The phenotypes of MS were also identified. Frailty was measured using a frailty index (FI), computed by cumulatively considering 42 age-related multidimensional health deficits.<br />Results: Overall, 745 MS patients (mean age = 48.2 years, standard deviation = 11.7 years; women 68%) were considered. The median FI value was 0.12 (interquartile range = 0.05-0.19) and the 99th percentile was 0.40. FI scores were associated with MS disease duration, disability, fatigue, as well as with the number of previous disease-modifying treatments and current symptomatic therapies. A logistic regression analysis model showed that FI score was independently associated with the secondary progressive phenotype.<br />Conclusion: Frailty is significantly associated with major characteristics of MS. The findings of the present cross-sectional investigation should be explored in future longitudinal studies.
Details
- Language :
- English
- ISSN :
- 1477-0970
- Volume :
- 27
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Publication Type :
- Academic Journal
- Accession number :
- 33565913
- Full Text :
- https://doi.org/10.1177/1352458520987541