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A prospective study into change of vitamin D levels, depression and frailty among depressed older persons.
- Source :
-
International journal of geriatric psychiatry [Int J Geriatr Psychiatry] 2021 Jul; Vol. 36 (7), pp. 1029-1036. Date of Electronic Publication: 2021 Feb 25. - Publication Year :
- 2021
-
Abstract
- Objectives: While vitamin D is involved in frailty as well as depression, hardly any study has examined the course of vitamin D levels prospectively. The objective of this study is to examine whether a change of vitamin D in depressed older adults is associated with either depression course, course of frailty, or both.<br />Methods: The study population consisted of 232 of 378 older adults (60-93 years) with a DSM-IV defined depressive disorder participating in the Netherlands Study of Depression in Older persons, a prospective clinical cohort study. Baseline and 2-year follow-up data on depressive disorder (DSM-IV diagnosis), symptom severity (inventory of depressive symptoms), frailty phenotype (and its individual components) and vitamin D levels were obtained. Linear mixed models were used to study the association of change in vitamin D levels with depression course, course of frailty, and the combination.<br />Results: Vitamin D levels decreased from baseline to follow-up, independent from depression course. An increase in frailty was associated with a significantly sharper decrease of vitamin D levels over time. Post hoc analyses showed that this association with frailty might be driven by an increase of exhaustion over time and counteracted by an increase in walking speed.<br />Conclusions: Our findings generate the hypothesis that vitamin D supplementation in late-life depression may improve frailty, which may partly explain inconsistent findings of randomised controlled trials evaluating the effect of vitamin D for depression. We advocate to consider frailty (components) as an outcome in future supplementation trials in late-life depression.<br /> (© 2021 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1099-1166
- Volume :
- 36
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of geriatric psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 33559131
- Full Text :
- https://doi.org/10.1002/gps.5507