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Influence of partial replacement of starch by sucrose in high fat-cholesterol diet on serum lipoprotein responses of cynomolgus monkeys.
- Source :
-
Biochemical medicine and metabolic biology [Biochem Med Metab Biol] 1988 Feb; Vol. 39 (1), pp. 31-9. - Publication Year :
- 1988
-
Abstract
- The influence of partial replacement of starch by sucrose on dietary cholesterol-induced serum lipoprotein responses was examined in 10 male cynomolgus monkeys (Macaca fascicularis). In a crossover design two semipurified diets provided either starch or starch and sucrose (1:1) as carbohydrate (49% by calories) with 0.4 mg cholesterol/kcal. Six weeks of starch + sucrose diet resulted in significantly reduced levels (mean +/- SE, mg/dl) of serum total cholesterol (264 +/- 9 vs 244 +/- 8) and apo B (110 +/- 6 vs 96 +/- 6) when compared with starch diet, whereas serum triglyceride levels remained similar between diets. With respect to changes in lipids and apolipoproteins (A-I or B) of very low (VLDL), low (LDL), intermediate (IDL), and high (HDL) density lipoproteins, starch + sucrose diet significantly increased VLDL-apo B (+34%), and decreased LDL-cholesterol (-18%) and LDL-apo B (-15%) as compared with starch alone; no differences were found in IDL and HDL between diets. The relative proportion of starch to sucrose in a diet appears to influence the magnitude of response of lipoproteins to dietary cholesterol.
Details
- Language :
- English
- ISSN :
- 0885-4505
- Volume :
- 39
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical medicine and metabolic biology
- Publication Type :
- Academic Journal
- Accession number :
- 3355713
- Full Text :
- https://doi.org/10.1016/0885-4505(88)90055-2