BOK-MCL1 transmembrane interactions: a challenging target for cancer therapy.

Authors :: Sancho M
Orzáez M
Source :: Molecular & cellular oncology [Mol Cell Oncol] 2021 Jan 11; Vol. 8 (1), pp. 1859918. Date of Electronic Publication: 2021 Jan 11.
Publication Year :: 2021
Abstract: Myeloid cell leukemia 1 ( MCL1 ) gene amplification occurs in a wide range of human cancers and protein overexpression associates with malignant cell growth and evasion of apoptosis. We recently reported that disrupting the interaction between the transmembrane domains of MCL1 and BCL-2 related ovarian killer (BOK) induces cell death, thereby suggesting a new target site for anti-tumorigenic strategies.<br /> (© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.)