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A Potential Role of the Renin-Angiotensin-System for Disturbances of Respiratory Chemosensitivity in Acute Respiratory Distress Syndrome and Severe Acute Respiratory Syndrome.
- Source :
-
Frontiers in physiology [Front Physiol] 2021 Jan 20; Vol. 11, pp. 588248. Date of Electronic Publication: 2021 Jan 20 (Print Publication: 2020). - Publication Year :
- 2021
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Abstract
- Acute respiratory distress syndrome (ARDS) represents an acute diffuse inflammation of the lungs triggered by different causes, uniformly leading to a noncardiogenic pulmonary edema with inhomogeneous densities in lung X-ray and lung CT scan and acute hypoxemia. Edema formation results in "heavy" lungs, inducing loss of compliance and the need to spend more energy to "move" the lungs. Consequently, an ARDS patient, as long as the patient is breathing spontaneously, has an increased respiratory drive to ensure adequate oxygenation and CO <subscript>2</subscript> removal. One would expect that, once the blood gases get back to "physiological" values, the respiratory drive would normalize and the breathing effort return to its initial status. However, in many ARDS patients, this is not the case; their respiratory drive appears to be upregulated and fully or at least partially detached from the blood gas status. Strikingly, similar alteration of the respiratory drive can be seen in patients suffering from SARS, especially SARS-Covid-19. We hypothesize that alterations of the renin-angiotensin-system (RAS) related to the pathophysiology of ARDS and SARS are involved in this dysregulation of chemosensitive control of breathing.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Hülsmann, Khabbazzadeh, Meissner and Quintel.)
Details
- Language :
- English
- ISSN :
- 1664-042X
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Frontiers in physiology
- Publication Type :
- Academic Journal
- Accession number :
- 33551831
- Full Text :
- https://doi.org/10.3389/fphys.2020.588248