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Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal.
- Source :
-
Cell calcium [Cell Calcium] 2021 Mar; Vol. 94, pp. 102359. Date of Electronic Publication: 2021 Jan 29. - Publication Year :
- 2021
-
Abstract
- Dopamine is a neuromodulator and neurotransmitter responsible for a number of physiological processes. Dysfunctions of the dopamine metabolism and signalling are associated with neurological and psychiatric diseases. Here we report that in primary co-culture of neurons and astrocytes dopamine-induces calcium signal in astrocytes and suppress spontaneous synchronous calcium oscillations (SSCO) in neurons. Effect of dopamine on SSCO in neurons was dependent on calcium signal in astrocytes and could be modified by inhibition of dopamine-induced calcium signal or by stimulation of astrocytic calcium rise with ATP. Ability of dopamine to suppress SSCO in neurons was independent on D1- or D2- like receptors but dependent on GABA and alpha-adrenoreceptors. Inhibitor of monoaminoxidase bifemelane blocked effect of dopamine on astrocytes but also inhibited the effect dopamine on SSCO in neurons. These findings suggest that dopamine-induced calcium signal may stimulate release of neuromodulators such as GABA and adrenaline and thus suppress spontaneous calcium oscillations in neurons.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adenosine Triphosphate metabolism
Animals
Astrocytes drug effects
Cells, Cultured
Chloride Channels metabolism
Dopamine Agonists pharmacology
GABA Antagonists pharmacology
Ion Channel Gating drug effects
Male
Neurons drug effects
Rats, Sprague-Dawley
Receptors, Adrenergic metabolism
Receptors, Dopamine D1 metabolism
Receptors, Dopamine D2 metabolism
Receptors, GABA metabolism
Rats
Astrocytes metabolism
Calcium Signaling drug effects
Dopamine metabolism
Neurons metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1991
- Volume :
- 94
- Database :
- MEDLINE
- Journal :
- Cell calcium
- Publication Type :
- Academic Journal
- Accession number :
- 33550209
- Full Text :
- https://doi.org/10.1016/j.ceca.2021.102359