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A comparison of characteristics and outcomes of patients with community-acquired and hospital-acquired COVID-19 in the United Kingdom: An observational study.
- Source :
-
Respiratory medicine [Respir Med] 2021 Mar; Vol. 178, pp. 106314. Date of Electronic Publication: 2021 Jan 28. - Publication Year :
- 2021
-
Abstract
- Background and Objectives: Reports comparing the characteristics of patients and their clinical outcomes between community-acquired (CA) and hospital-acquired (HA) COVID-19 have not yet been reported in the literature. We aimed to characterise and compare clinical, biochemical and haematological features, in addition to clinical outcomes, between these patients.<br />Methods: This multi-centre, retrospective, observational study enrolled 488 SARS-CoV-2 positive patients - 339 with CA infection and 149 with HA infection. All patients were admitted to a hospital within the University Hospitals of Morecambe Bay NHS Foundation Trust between March 7th and May 18th <superscript>,</superscript> 2020.<br />Results: The CA cohort comprised of a significantly younger population, median age 75 years, versus 80 years in the HA cohort (P = 0·0002). Significantly less patients in the HA group experienced fever (P = 0·03) and breathlessness (P < 0·0001). Furthermore, significantly more patients had anaemia and hypoalbuminaemia in the HA group, compared to the CA group (P < 0·0001 for both). Hypertension and a lower median BMI were also significantly more pronounced in the HA cohort (P = 0·03 and P = 0·0001, respectively). The mortality rate was not significantly different between the two cohorts (34% in the CA group and 32% in the HA group, P = 0·64). However, the CA group required significantly greater ICU care (10% versus 3% in the HA group, P = 0·009).<br />Conclusion: Hospital-acquired and community-acquired COVID-19 display similar rates of mortality despite significant differences in baseline characteristics of the respective patient populations. Delineation of community- and hospital-acquired COVID-19 in future studies on COVID-19 may allow for more accurate interpretation of results.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
COVID-19 diagnosis
Community-Acquired Infections diagnosis
Cross Infection diagnosis
Female
Hospital Mortality
Hospitalization
Humans
Male
Middle Aged
Retrospective Studies
Survival Rate
Symptom Assessment
United Kingdom
Young Adult
COVID-19 complications
COVID-19 mortality
Community-Acquired Infections complications
Community-Acquired Infections mortality
Cross Infection complications
Cross Infection mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3064
- Volume :
- 178
- Database :
- MEDLINE
- Journal :
- Respiratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33550150
- Full Text :
- https://doi.org/10.1016/j.rmed.2021.106314