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Brain activation during verbal fluency task in type II bipolar disorder patients: a near-infrared spectroscopy study.

Authors :
Chen GF
Mao MC
Feng K
Gan JC
Zhang XQ
Shen CY
Xu B
Liu XM
Ren XJ
Liu PZ
Wang Y
Source :
Psychiatry research [Psychiatry Res] 2021 Apr; Vol. 298, pp. 113762. Date of Electronic Publication: 2021 Jan 26.
Publication Year :
2021

Abstract

Background: Previous studies have shown that BD patients exhibited impairment when performing a verbal fluency task (VFT) and abnormal prefrontal cortex activation during this task. However, no study has specifically examined whether patients with type II BD demonstrate difficulty in performing VFT and impairments in relevant neural correlates or whether these are related to psychotic symptoms, the present study aimed to examine these issues.<br />Methods: Forty-nine patients with type II BD (21 patients with psychotic symptoms [BDIIp] and 28 patients without psychotic symptoms [BDIIn]) and 45 matched healthy controls (HCs) participated the study and completed the VFTs, while their brain activity was recorded with near-infrared spectroscopy (NIRS).<br />Results: Both BDIIp and BDIIn patients showed poorer performance on VFTs than HCs. In addition, BDII patients showed lower brain activation than HCs in bilateral dorsolateral prefrontal cortex and right frontal pole, these results were mainly driven by BDIIn patients. Moreover, subjective psychotic symptoms were positively significantly correlated with left dorsolateral prefrontal cortex activation in BDII patients.<br />Conclusions: Type II BD patients showed significant impairment when performing VFTs and reduced activation in the prefrontal cortex, and subjective psychotic symptoms were associated with brain activation in left dorsolateral prefrontal cortex in BDII patients.<br /> (Copyright © 2021. Published by Elsevier B.V.)

Details

Language :
English
ISSN :
1872-7123
Volume :
298
Database :
MEDLINE
Journal :
Psychiatry research
Publication Type :
Academic Journal
Accession number :
33545426
Full Text :
https://doi.org/10.1016/j.psychres.2021.113762