Ti(O i Pr) 4 -Facilitated Formal Deoxygenative Annulation of Alkynyl 1,2-Diketones for the Synthesis of Highly Functionalized Furans.

Authors :: Lan S
Liu R
Kong X
Liu J
Luo B
Yang S
Fang X
Source :: Organic letters [Org Lett] 2021 Feb 19; Vol. 23 (4), pp. 1504-1509. Date of Electronic Publication: 2021 Feb 03.
Publication Year :: 2021
Abstract: A unique deoxygenative cyclodimerization of alkynyl 1,2-diketones facilitated by Ti(O <superscript> i </superscript> Pr) <subscript>4</subscript> is achieved, affording a series of highly functionalized furan products. An unusual C-C bond and C═O bond cleavage of the substrates is observed, and Ti(O <superscript> i </superscript> Pr) <subscript>4</subscript> plays triplicate roles in the reaction. Furthermore, the products show uncommon fluorescent emission in the solid state, indicating the potential practical applications of this work.

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