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Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2021 Apr; Vol. 141 (4S), pp. 1017-1023. Date of Electronic Publication: 2021 Jan 30. - Publication Year :
- 2021
-
Abstract
- The mammalian skin is essential to protect the organism from external damage while at the same time enabling communication with the environment. Aging compromises skin function and regeneration, which is further exacerbated by external influences, such as UVR from the sun. Aging and UVR are also major risk factors contributing to the development of skin cancer. Whereas aging research traditionally has focused on the role of DNA damage and metabolic and stress pathways, less is known about how aging affects tissue architecture and cell dynamics in skin homeostasis and regeneration and whether changes in these processes promote skin cancer. This review highlights how key regulators of cell polarity and adhesion affect epidermal mechanics, tissue architecture, and stem cell dynamics in skin aging and cancer.<br /> (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Cell Adhesion genetics
Cell Adhesion radiation effects
Cell Polarity radiation effects
DNA Damage radiation effects
Disease Models, Animal
Epidermis radiation effects
Humans
Mice
Regeneration genetics
Regeneration radiation effects
Skin Aging radiation effects
Skin Neoplasms etiology
Stem Cells
Ultraviolet Rays adverse effects
Cell Polarity genetics
Epidermis pathology
Skin Aging genetics
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 141
- Issue :
- 4S
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 33531135
- Full Text :
- https://doi.org/10.1016/j.jid.2020.12.012