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Caffeine exposure in utero is associated with structural brain alterations and deleterious neurocognitive outcomes in 9-10 year old children.
- Source :
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Neuropharmacology [Neuropharmacology] 2021 Mar 15; Vol. 186, pp. 108479. Date of Electronic Publication: 2021 Jan 30. - Publication Year :
- 2021
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Abstract
- Caffeine, a very widely used and potent neuromodulator, easily crosses the placental barrier, but relatively little is known about the long-term impact of gestational caffeine exposure (GCE) on neurodevelopment. Here, we leverage magnetic resonance imaging (MRI) data, collected from a very large sample of 9157 children, aged 9-10 years, as part of the Adolescent Brain and Cognitive Development <superscript>sm</superscript> (ABCD ®) study, to investigate brain structural outcomes at 27 major fiber tracts as a function of GCE. Significant relationships between GCE and fractional anisotropy (FA) measures in the inferior fronto-occipito fasciculus and corticospinal tract of the left hemisphere (IFOF-LH; CST-LH) were detected via mixed effects binomial regression. We further investigated the interaction between these fiber tracts, GCE, cognitive measures (working memory, task efficiency), and psychopathology measures (externalization, internalization, somatization, and neurodevelopment). GCE was associated with poorer outcomes on all measures of psychopathology but had negligible effect on cognitive measures. Higher FA values in both fiber tracts were associated with decreased neurodevelopmental problems and improved performance on both cognitive tasks. We also identified a decreased association between FA in the CST-LH and task efficiency in the GCE group. These findings suggest that GCE can lead to future neurodevelopmental complications and that this occurs, in part, through alteration of the microstructure of critical fiber tracts such as the IFOF-LH and CST-LH. These data suggest that current guidelines regarding limiting caffeine intake during pregnancy may require some recalibration.<br /> (Copyright © 2021. Published by Elsevier Ltd.)
- Subjects :
- Brain diagnostic imaging
Caffeine administration & dosage
Central Nervous System Stimulants administration & dosage
Central Nervous System Stimulants adverse effects
Child
Developmental Disabilities chemically induced
Developmental Disabilities diagnostic imaging
Developmental Disabilities psychology
Female
Humans
Longitudinal Studies
Male
Neurocognitive Disorders chemically induced
Neurocognitive Disorders diagnostic imaging
Neurocognitive Disorders psychology
Pregnancy
Prenatal Exposure Delayed Effects diagnostic imaging
Brain drug effects
Brain growth & development
Caffeine adverse effects
Mental Status and Dementia Tests
Prenatal Exposure Delayed Effects chemically induced
Prenatal Exposure Delayed Effects psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7064
- Volume :
- 186
- Database :
- MEDLINE
- Journal :
- Neuropharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 33529676
- Full Text :
- https://doi.org/10.1016/j.neuropharm.2021.108479