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Knockdown of PC4 increases chemosensitivity of Oxaliplatin in triple negative breast cancer by suppressing mTOR pathway.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Mar 12; Vol. 544, pp. 65-72. Date of Electronic Publication: 2021 Jan 29. - Publication Year :
- 2021
-
Abstract
- As a multifunctional nuclear protein, the human positive cofactor 4 (PC4) is highly expressed in various tumors including breast cancer and has potential roles in cancer development and progression. However, the functional signatures and molecular mechanisms of PC4 in triple negative breast cancer (TNBC) progression and chemotherapeutic response are still unknown. In this study, we found that PC4 is significantly upregulated in TNBC cells compared with non-TNBC cells, implying its potential role in TNBC. Then, in vivo and in vitro studies revealed that knockdown of PC4 increased chemosensitivity of Oxaliplation (Oxa) in TNBC by suppressing mTOR pathway. Therefore, our findings demonstrated the signatures and molecular mechanisms of PC4 in TNBC chemotherapeutic response, and indicated that PC4 might be a promising therapeutic target for TNBC.<br />Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.<br /> (Copyright © 2021. Published by Elsevier Inc.)
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Cell Line, Tumor
Cell Proliferation
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Female
Humans
Mice
Mice, Nude
Phosphorylation
Signal Transduction
Transcription Factors genetics
Transcription Factors metabolism
Triple Negative Breast Neoplasms metabolism
Triple Negative Breast Neoplasms pathology
Up-Regulation
DNA-Binding Proteins antagonists & inhibitors
Drug Resistance, Neoplasm
Gene Knockdown Techniques methods
Oxaliplatin pharmacology
TOR Serine-Threonine Kinases antagonists & inhibitors
Transcription Factors antagonists & inhibitors
Triple Negative Breast Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 544
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 33524870
- Full Text :
- https://doi.org/10.1016/j.bbrc.2021.01.029