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Knockdown of PC4 increases chemosensitivity of Oxaliplatin in triple negative breast cancer by suppressing mTOR pathway.

Authors :
Wang Q
Ma L
Chen L
Chen H
Luo M
Yang W
Liao F
Gong Q
Wang Y
Yang Z
Wu J
Zhang C
Zheng J
Han S
Leng Y
Luo P
Shi C
Source :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Mar 12; Vol. 544, pp. 65-72. Date of Electronic Publication: 2021 Jan 29.
Publication Year :
2021

Abstract

As a multifunctional nuclear protein, the human positive cofactor 4 (PC4) is highly expressed in various tumors including breast cancer and has potential roles in cancer development and progression. However, the functional signatures and molecular mechanisms of PC4 in triple negative breast cancer (TNBC) progression and chemotherapeutic response are still unknown. In this study, we found that PC4 is significantly upregulated in TNBC cells compared with non-TNBC cells, implying its potential role in TNBC. Then, in vivo and in vitro studies revealed that knockdown of PC4 increased chemosensitivity of Oxaliplation (Oxa) in TNBC by suppressing mTOR pathway. Therefore, our findings demonstrated the signatures and molecular mechanisms of PC4 in TNBC chemotherapeutic response, and indicated that PC4 might be a promising therapeutic target for TNBC.<br />Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.<br /> (Copyright © 2021. Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1090-2104
Volume :
544
Database :
MEDLINE
Journal :
Biochemical and biophysical research communications
Publication Type :
Academic Journal
Accession number :
33524870
Full Text :
https://doi.org/10.1016/j.bbrc.2021.01.029