The Effect of Soluble TREM-1 in Idiopathic Granulomatous Mastitis.

Background and Objectives: The aim of this study is to investigate the effect of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in idiopathic granulomatous mastitis (IGM).
Methods: This case-control study was conducted in Saglik Bilimleri and Necmettin Erbakan Universities. Sixty patients with IGM diagnosis (Group P) and 25 healthy females as control group (Group C) were included. Group P was divided into two subgroups according to the activity of disease: patients with active lesion (Group P _A ), and patients without any symptoms, in remission (Group P _R ). The ELISA method was used to measure sTREM-1 level.
Results: Group P's sTREM-1 were higher than Group C ( p < .0001). The difference between sTREM-1 levels of Groups P _A , P _R and C was significant statistically ( p < .0001). Group P _A 's sTREM-1 levels were higher than Group C ( p < .0001). Also, sTREM-1 levels of Group P _R were higher than Group C ( p = .006). When sTREM-1 levels of patients receiving steroid therapy and did not in Group P _R were analyzed, the sTREM-1 levels of the patients not receiving steroid treatment were found to be statistically higher than Group C ( p = .002). Although the sTREM-1 levels of the patients who did not receive steroid therapy were higher than those who received steroid therapy, the difference was not statistically significant ( p > .05).
Conclusion: We concluded that the detected high sTREM-1 levels contributed to inflammation in IGM. In particular, blockade of TREM may be a promising treatment option in resistant or multiple recurrent patients.