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TOR Signaling Pathway in Cardiac Aging and Heart Failure.

Authors :
Daneshgar N
Rabinovitch PS
Dai DF
Source :
Biomolecules [Biomolecules] 2021 Jan 27; Vol. 11 (2). Date of Electronic Publication: 2021 Jan 27.
Publication Year :
2021

Abstract

Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. Over the past two decades, studies on the mTOR pathway have revealed that mTOR complex 1 controls life span, health span, and aging by modulating key cellular processes such as protein synthesis, autophagy, and mitochondrial function, mainly through its downstream substrates. Thus, the mTOR pathway regulates both physiological and pathological processes in the heart from embryonic cardiovascular development to maintenance of cardiac homeostasis in postnatal life. In this regard, the dysregulation of mTOR signaling has been linked to many age-related pathologies, including heart failure and age-related cardiac dysfunction. In this review, we highlight recent advances of the impact of mTOR complex 1 pathway and its regulators on aging and, more specifically, cardiac aging and heart failure.

Details

Language :
English
ISSN :
2218-273X
Volume :
11
Issue :
2
Database :
MEDLINE
Journal :
Biomolecules
Publication Type :
Academic Journal
Accession number :
33513917
Full Text :
https://doi.org/10.3390/biom11020168