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Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs.
- Source :
-
Genes [Genes (Basel)] 2021 Jan 27; Vol. 12 (2). Date of Electronic Publication: 2021 Jan 27. - Publication Year :
- 2021
-
Abstract
- Hernia is one of the most common defects in pigs. The most prevalent are the scrotal (SH), inguinal (IH) and umbilical (UH) hernias. We compared the inguinal ring transcriptome of normal and SH-affected pigs with the umbilical ring transcriptome of normal and UH-affected pigs to discover genes and pathways involved with the development of both types of hernia. A total of 13,307 transcripts was expressed in the inguinal and 13,302 in the umbilical ring tissues with 94.91% of them present in both tissues. From those, 35 genes were differentially expressed in both groups, participating in 108 biological processes. A total of 67 polymorphisms was identified in the inguinal ring and 76 in the umbilical ring tissue, of which 11 and 14 were novel, respectively. A single nucleotide polymorphism (SNP) with deleterious function was identified in the integrin α M ( ITGAM ) gene. The microtubule associated protein 1 light chain 3 γ ( MAP1LC3C ), vitrin ( VIT ), aggrecan ( ACAN ), alkaline ceramidase 2 ( ACER2 ), potassium calcium-activated channel subfamily M α 1 ( KCNMA1 ) and synaptopodin 2 ( SYNPO2 ) genes are highlighted as candidates to trigger both types of hernia. We generated the first comparative study of the pig umbilical and inguinal ring transcriptomes, contributing to the understanding of the genetic mechanism involved with these two types of hernia in pigs and probably in other mammals.
- Subjects :
- Animals
Biopsy
Chromosome Mapping
Gene Expression Profiling
Gene Regulatory Networks
Immunohistochemistry
Male
Swine
Transcriptome
Genetic Predisposition to Disease
Hernia, Umbilical veterinary
Hernia, Ventral veterinary
Polymorphism, Single Nucleotide
Scrotum pathology
Swine Diseases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4425
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Genes
- Publication Type :
- Academic Journal
- Accession number :
- 33513662
- Full Text :
- https://doi.org/10.3390/genes12020166