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Management of Allogeneic Stem Cell Transplantation for High-Risk AML following SARS-CoV-2 Associated Pancytopenia with Marked Bone Marrow Biopsy Alterations.
- Source :
-
Case reports in hematology [Case Rep Hematol] 2021 Jan 21; Vol. 2021, pp. 8843063. Date of Electronic Publication: 2021 Jan 21 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- The present study describes a patient aged 70 with very high-risk AML who successfully received a nonmyeloablative matched unrelated donor allograft shortly following SARS-CoV-2 infection, which manifested with mild cough, interstitial abnormalities on chest CT, and pancytopenia with profound bone marrow biopsy histological alterations. In parallel, our study provides bone marrow biopsy data in a series of contemporary patients with serious haematological diseases who had a bone marrow biopsy performed within two weeks of PCR confirmation of SARS-CoV-2 infection. This study is notable because there are no published data describing the bone marrow biopsy changes observed in patients with haematological malignancies and SARS-CoV-2 infection. Finally, it is suggested that nonmyeloablative hematopoietic stem cell transplantation for very high-risk haematological malignancies can be successfully performed following recovery from SARS-CoV-2 infection.<br />Competing Interests: The authors declare no conflicts of interest were associated with this study.<br /> (Copyright © 2021 Maria Kaparou et al.)
Details
- Language :
- English
- ISSN :
- 2090-6560
- Volume :
- 2021
- Database :
- MEDLINE
- Journal :
- Case reports in hematology
- Publication Type :
- Report
- Accession number :
- 33510919
- Full Text :
- https://doi.org/10.1155/2021/8843063