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Transdermal electroosmotic flow generated by a porous microneedle array patch.
- Source :
-
Nature communications [Nat Commun] 2021 Jan 28; Vol. 12 (1), pp. 658. Date of Electronic Publication: 2021 Jan 28. - Publication Year :
- 2021
-
Abstract
- A microneedle array is an attractive option for a minimally invasive means to break through the skin barrier for efficient transdermal drug delivery. Here, we report the applications of solid polymer-based ion-conductive porous microneedles (PMN) containing interconnected micropores for improving iontophoresis, which is a technique of enhancing transdermal molecular transport by a direct current through the skin. The PMN modified with a charged hydrogel brings three innovative advantages in iontophoresis at once: (1) lowering the transdermal resistance by low-invasive puncture of the highly resistive stratum corneum, (2) transporting of larger molecules through the interconnected micropores, and (3) generating electroosmotic flow (EOF). In particular, the PMN-generated EOF greatly enhances the transdermal molecular penetration or extraction, similarly to the flow induced by external pressure. The enhanced efficiencies of the EOF-assisted delivery of a model drug (dextran) and of the extraction of glucose are demonstrated using a pig skin sample. Furthermore, the powering of the PMN-based transdermal EOF system by a built-in enzymatic biobattery (fructose / O <subscript>2</subscript> battery) is also demonstrated as a possible totally organic iontophoresis patch.
- Subjects :
- Administration, Cutaneous
Animals
Dextrans administration & dosage
Dextrans metabolism
Dextrans pharmacokinetics
Electroosmosis
Fluorescein-5-isothiocyanate administration & dosage
Fluorescein-5-isothiocyanate analogs & derivatives
Fluorescein-5-isothiocyanate metabolism
Fluorescein-5-isothiocyanate pharmacokinetics
Glucose administration & dosage
Glucose metabolism
Glucose pharmacokinetics
Humans
Iontophoresis instrumentation
Iontophoresis methods
Male
Microinjections
Needles
Pathogen-Associated Molecular Pattern Molecules administration & dosage
Pathogen-Associated Molecular Pattern Molecules metabolism
Pathogen-Associated Molecular Pattern Molecules pharmacokinetics
Porosity
Swine
Drug Delivery Systems instrumentation
Drug Delivery Systems methods
Epidermis metabolism
Skin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 33510169
- Full Text :
- https://doi.org/10.1038/s41467-021-20948-4