Back to Search Start Over

Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013-2020.

Authors :
Fabeni L
Rozera G
Berno G
Giombini E
Gori C
Orchi N
De Carli G
Pittalis S
Puro V
Pinnetti C
Mondi A
Camici M
Plazzi MM
Antinori A
Capobianchi MR
Abbate I
Source :
Viruses [Viruses] 2021 Jan 25; Vol. 13 (2). Date of Electronic Publication: 2021 Jan 25.
Publication Year :
2021

Abstract

Molecular investigation of primary HIV infections (PHI) is crucial to describe current dynamics of HIV transmission. Aim of the study was to investigate HIV transmission clusters (TC) in PHI referred during the years 2013-2020 to the National Institute for Infectious Diseases in Rome (INMI), that is the Lazio regional AIDS reference centre, and factors possibly associated with inclusion in TC. These were identified by phylogenetic analysis, based on population sequencing of pol ; a more in depth analysis was performed on TC of B subtype, using ultra-deep sequencing (UDS) of env . Of 270 patients diagnosed with PHI during the study period, 229 were enrolled (median follow-up 168 (IQR 96-232) weeks). Median age: 39 (IQR 32-48) years; 94.8% males, 86.5% Italians, 83.4% MSM, 56.8% carrying HIV-1 subtype B. Of them, 92.6% started early treatment within a median of 4 (IQR 2-7) days after diagnosis; median time to sustained suppression was 20 (IQR 8-32) weeks. Twenty TC (median size 3, range 2-9 individuals), including 68 patients, were identified. A diagnosis prior to 2015 was the unique factor associated with inclusion in a TC. Added value of UDS was the identification of shared quasispecies components in transmission pairs within TC.

Details

Language :
English
ISSN :
1999-4915
Volume :
13
Issue :
2
Database :
MEDLINE
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
33503987
Full Text :
https://doi.org/10.3390/v13020176