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Bioactive Betulin and PEG Based Polyanhydrides for Use in Drug Delivery Systems.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 22; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 22. - Publication Year :
- 2021
-
Abstract
- In the course of this study, a series of novel, biodegradable polyanhydrides based on betulin disuccinate and dicarboxylic derivatives of poly(ethylene glycol) were prepared by two-step polycondensation. These copolymers can be used as carriers in drug delivery systems, in the form of microspheres. Betulin and its derivatives exhibit a broad spectrum of biological activity, including cytotoxic activity, which makes them promising substances for use as therapeutic agents. Microspheres that were prepared from betulin based polyanhydrides show promising properties for use in application in drug delivery systems, including inhalation systems. The obtained copolymers release the active substance-betulin disuccinate-as a result of hydrolysis under physiological conditions. The use of a poly(ethylene glycol) derivative as a co-monomer increases the solubility and bioavailability of the obtained compounds. Microspheres with diameters in the range of 0.5-25 µm were prepared by emulsion solvent evaporation method and their physicochemical and aerodynamic properties were analyzed. The morphological characteristics of the microspheres depended on the presence of poly(ethylene glycol) (PEG) segment within the structure of polyanhydrides. The porosity of the particles depended on the amount and molecular weight of the PEG used and also on the speed of homogenization. The most porous particles were obtained from polyanhydrides containing 20% wt. of PEG 600 by using a homogenization speed of 18,000 rpm.
- Subjects :
- A549 Cells
Aerosols
Cell Line, Tumor
Drug Carriers chemistry
HeLa Cells
Hep G2 Cells
Humans
Hydrogen-Ion Concentration
Hydrolysis
MCF-7 Cells
Magnetic Resonance Spectroscopy
Microspheres
Molecular Weight
Particle Size
Polymers chemistry
Porosity
Solvents
Drug Delivery Systems
Phytochemicals chemistry
Polyanhydrides chemistry
Polyethylene Glycols chemistry
Triterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33499242
- Full Text :
- https://doi.org/10.3390/ijms22031090