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Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus.
- Source :
-
Diabetologia [Diabetologia] 2021 Apr; Vol. 64 (4), pp. 845-849. Date of Electronic Publication: 2021 Jan 26. - Publication Year :
- 2021
-
Abstract
- Aims/hypothesis: Our aim was to investigate the relationship between average blood glucose levels and incident CHD in individuals without diabetes mellitus.<br />Methods: To investigate average blood glucose levels, we studied HbA <subscript>1c</subscript> as predicted by 40 variants previously shown to be associated with both type 2 diabetes and HbA <subscript>1c</subscript> . Linear and non-linear Mendelian randomisation analyses were performed to investigate associations with incident CHD risk in 324,830 European ancestry individuals from the UK Biobank without diabetes mellitus.<br />Results: Every one mmol/mol increase in genetically proxied HbA <subscript>1c</subscript> was associated with an 11% higher CHD risk (HR 1.11, 95% CI 1.05, 1.18). The dose-response curve increased at all levels of HbA <subscript>1c</subscript> , and there was no evidence favouring a non-linear relationship over a linear one.<br />Conclusions/interpretations: In individuals without diabetes mellitus, lowering average blood glucose levels may reduce CHD risk in a dose-dependent way.
- Subjects :
- Adult
Aged
Biomarkers blood
Coronary Disease blood
Coronary Disease diagnosis
Coronary Disease epidemiology
Female
Genetic Predisposition to Disease
Humans
Incidence
Male
Mendelian Randomization Analysis
Middle Aged
Phenotype
Time Factors
United Kingdom epidemiology
Blood Glucose metabolism
Coronary Disease genetics
Glycated Hemoglobin metabolism
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0428
- Volume :
- 64
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 33495845
- Full Text :
- https://doi.org/10.1007/s00125-020-05377-0