Oral S-ketamine effective after deep brain stimulation in severe treatment-resistant depression and extensive comorbidities.

This case report describes successful maintenance treatment with oral S-ketamine in a patient with severe depression, who previously was resistant to electroconvulsive therapy and deep brain stimulation, and who also had comorbid psychotic and obsessive compulsive symptoms.
Competing Interests: Competing interests: JKEV received a speaker's honorarium from Janssen, outside the submitted work. RAS has received research funding for two randomised clinical trials with generic oral esketamine from the Netherlands Organisation for Health Research & Development and the National Health Care Institute, a speaker's fee from Janssen and consultancy fee from Clexio Biosciences, both outside the submitted work.
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