Hemangioblastoma: An Unsuspected Pitfall in PSMA PET/CT.

Authors :: Gohimont N
Jissendi Tchofo P
Racu ML
Entezari K
Salmon I
Tondeur M
Ene D
Source :: Clinical nuclear medicine [Clin Nucl Med] 2021 Jun 01; Vol. 46 (6), pp. 485-487.
Publication Year :: 2021
Abstract: Abstract: Hemangioblastoma (HB) is the most common primary intra-axial posterior fossa tumor in adults and is a benign vascular neoplasm. We report the case of a 73-year-old man suffering from biochemical recurrence of prostate cancer where intense overexpression of prostate-specific membrane antigen (PSMA) was observed in HB in a PSMA PET/CT. Overexpression of PSMA in tumor-associated vascular structures has been proposed as an explanation of PSMA ligand uptake in several nonprostatic tumors. Given the pathological nature of HB, this mechanism may explain the intense overexpression of PSMA observed in present case.<br />Competing Interests: Conflicts of interest and sources of funding: none declared.<br /> (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)