Adenosquamous carcinoma of the breast, an uncommon diagnosis with poor prognosis-Lessons learned from a 12-year analysis of the National Cancer Database.

Authors :: Cochrane K
Bell JL
Heidel RE
Orucevic A
Source :: The breast journal [Breast J] 2021 Feb; Vol. 27 (2), pp. 165-169. Date of Electronic Publication: 2021 Jan 22.
Publication Year :: 2021
Abstract: We compared the clinicopathologic characteristics and prognosis of adenosquamous carcinoma (ASQ) of the breast with invasive ductal carcinoma (IDC), utilizing the National Cancer Database (NCDB) from 2004 to 2015. 1 932 688 female patients had invasive breast carcinoma; 1 421 250 had IDC (73.5%); and 453 had ASQ (0.0002%). When compared to IDC, ASQ patients were significantly (P < .05) older and had grade 1 tumors; negative lymph nodes; ER/PR/HER2-negative tumors; and worse 5-year overall survival (64.9% vs 74%, respectively). Our study, largest to date on ASQ, revealed an aggressive carcinoma with a significantly worse prognosis than IDC. "Personalized medicine" treatment approach for patients with this uncommon carcinoma is needed.<br /> (© 2020 Wiley Periodicals LLC.)

Subjects :: Breast
Female
Humans
Prognosis
Breast Neoplasms diagnosis
Breast Neoplasms therapy
Carcinoma, Adenosquamous diagnosis
Carcinoma, Ductal, Breast

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